Brain theranostics: Peptides show critical care

Advancing theranostics with tumor-targeting peptides for precision otolaryngology

Worldwide, about 600,000 head and neck squamous cell carcinoma (HNSCC) are detected annually, many of which involve high risk human papilloma virus (HPV). Surgery is the primary and desired first treatment option. Following surgery, the existence of cancer cells at the surgical margin is strongly associated with eventual recurrence of cancer and a poor outcome. Despite improved surgical methods...

Thalamocortical Inputs Show Post-Critical-Period Plasticity

Experience-dependent plasticity in the adult brain has clinical potential for functional rehabilitation following central and peripheral nerve injuries. Here, plasticity induced by unilateral infraorbital (IO) nerve resection in 4-week-old rats was mapped using MRI and synaptic mechanisms were elucidated by slice electrophysiology. Functional MRI demonstrates a cortical potentiation compared to...

Critical care management of severe traumatic brain injury in adults

Traumatic brain injury (TBI) is a major medical and socio-economic problem, and is the leading cause of death in children and young adults. The critical care management of severe TBI is largely derived from the "Guidelines for the Management of Severe Traumatic Brain Injury" that have been published by the Brain Trauma Foundation. The main objectives are prevention and treatment of intracranial...

Brain and gut peptides.

The first evidence that the same peptides could be present in both the brain and the gut was given in 1931 with the discovery of substance P (Von Euler and Gaddum, 1931). In spite of this early start, the important revelation that there were a large number of peptides with this dual localisation and also with powerful and extensive pharmacological actions took more than 40 years to materialise....

Critical Care Neurology and Neuro Critical Care